John Gill Commentary Ezekiel 35:3

"and say unto it, Thus saith the Lord Jehovah: Behold, I am against thee, O mount Seir, and I will stretch out my hand against thee, and I will make thee a desolation and an astonishment." — Ezekiel 35:3 (ASV)

And say unto it, thus says the Lord God
The prophet was not upon the spot, and could not direct his speech immediately to the Edomites; but he might send this prophecy to their ambassadors at Babylon; or in a letter to them in their own land, in the name of the Lord: behold, O Mount Seir, I am against you :
not the face of the prophet only, but the face of God himself was against them; and a terrible thing it is for any to have God to be against them, whether a nation, or a particular person. The Targum is, ``behold, I send my fury upon you:''

and I will stretch out my hand against you ;
which was able to reach them wherever they were. When stretched out, it cannot be turned back, and where it lands, it falls heavily indeed; namely, his mighty hand of power and wrath. The Targum is, ``and I will lift up the stroke of my power upon you;''

The consequence is as follows: and I will make you most desolate ;
their land, cities, towns, and villages, all should be utterly laid waste; see (Revelation 17:16) (18:8) , so it follows: