John Gill Commentary Ezekiel 35:4

"I will lay thy cities waste, and thou shalt be desolate; and thou shalt know that I am Jehovah." — Ezekiel 35:4 (ASV)

I will lay your cities waste

Such as Dedan, Teman, Bozrah, and other cities of Idumea mentioned in Scripture; and figuratively may design all within the jurisdiction of Rome, the several cities of the antichristian states, called "the cities of the nations"; which will fall at the pouring out of the vials, (Revelation 16:19).

and you shall be desolate

thoroughly and entirely, and remain so:

and you shall know that I am the Lord

that has done all this; that the hand of God was in it; and that this is a punishment inflicted by him, for their sins after mentioned; but not that they should know the Lord spiritually and savingly, and so as to yield obedience to him, and own and acknowledge him to be their God; though this may be the case of a remnant among them; see (Revelation 11:13) (18:4).