John Gill Commentary Genesis 22:17

"that in blessing I will bless thee, and in multiplying I will multiply thy seed as the stars of the heavens, and as the sand which is upon the seashore. And thy seed shall possess the gate of his enemies." — Genesis 22:17 (ASV)

That in blessing I will bless you With temporal and spiritual blessings; with the Spirit and all his graces; with Christ and redemption, justification, and salvation by him; and with eternal life, as the gift of God, through him: and in multiplying I will multiply your seed as the stars of the heaven, and as the sand which [is] upon the sea shore : both his natural seed, descending from him in the line of Isaac, and his spiritual seed, both among Jews and Gentiles, that tread in his steps; see (Genesis 13:15Genesis 13:16) (15:5) :

and your seed shall possess the gate of his enemies : "gate" for "gates", where courts of judicature were held, and which are the security of cities and put for them, and which also include the whole country round about: so that this phrase is expressive of an entire jurisdiction and dominion over them; and was literally fulfilled in the times of Joshua, David, and Solomon; and spiritually in Christ, Abraham's principal seed, when he destroyed Satan and his principalities and powers; overcame the world; made an end of sin and abolished death; and delivered his people out the hands of all their enemies; and in all Abraham's spiritual seed, who are made more than conquerors over them, through Christ that has loved them.