John Gill Commentary Genesis 28:2

"Arise, go to Paddan-aram, to the house of Bethuel thy mother`s father. And take thee a wife from thence of the daughters of Laban thy mother`s brother." — Genesis 28:2 (ASV)

Arise, go to Padanaram Of this place, (See Gill on Genesis 25:20); either he is bid to go directly, in haste and alone; perhaps by this time Rebekah had given Isaac some hint of the ill design of Esau against him, which made Isaac the more urgent upon him to be gone, as well as it was high time he had taken to himself a wife:

to the house of Bethuel your mother's father ; who though now dead in all probability, yet the house and family went by his name:

and take you a wife from thence of the daughters of Laban your mother's brother : who had daughters unmarried, of which no doubt Isaac and Rebekah had knowledge, a correspondence being kept up between the two families, though at a great distance.