John Gill Commentary Genesis 31:21

"So he fled with all that he had; and he rose up, and passed over the River, and set his face toward the mountain of Gilead." — Genesis 31:21 (ASV)

So he fled with all that he had His wives, his children, cattle and substance; and he rose up, and passed over the river ; the river Euphrates, as the Targum of Jonathan expresses it, which lay between Mesopotamia and Canaan; and set his face [toward] the mount Gilead : he travelled and bent his course that way: this, was a mountain on the border of the land of Canaan, adjoining to Lebanon, near which was a very fruitful country, which had its name from it: it is so called here by way of anticipation; for this name was afterwards given it from the heap of stones here laid, as a witness of the agreement between Laban and Jacob, (Genesis 31:45) .