John Gill Commentary Isaiah 43:22

"Yet thou hast not called upon me, O Jacob; but thou hast been weary of me, O Israel." — Isaiah 43:22 (ASV)

But you have not called upon me, O Jacob
The Jews, though they were the posterity of Jacob, a praying person, yet did not tread in his steps, but were more like the Heathens that called not on the name of the Lord; though there is no necessity of restraining this to prayer, it may regard the whole worship of God, which is sometimes included in the invocation of his name; and so the Targum, "and you come not to my worship, O you of the house of Jacob."

The Jews, in Christ's time, did not call upon his name, nor believe in him, nor receive his Gospel, nor submit to him and his ordinances; they rejected him and his service, therefore the Lord rejected them, and called the Gentiles, as before prophesied of.

but you have been weary of me, O Israel :
of the word, worship, and ordinances of God; see (Malachi 1:13) (Amos 8:5) .