John Gill Commentary Isaiah 48:19

"thy seed also had been as the sand, and the offspring of thy bowels like the grains thereof: his name would not be cut off nor destroyed from before me." — Isaiah 48:19 (ASV)

Your seed had also been as the sand
Upon the sea shore, as numerous as that, as was promised to Abraham, (Genesis 22:17) : and the offspring of your bowels as the gravel thereof ;
that is, of the sand; the little stones that are in it, which lie in great numbers on the sea shore; the same thing expressed in different words, denoting the number of their posterity, as it would have been, had they received the Messiah, his doctrines and ordinances: it may be rendered, "and the offspring", or "those that go out of your bowels", that spring from you, are born of you, "as the bowels thereof" ^F17 , that is, of the sea; as what is within it, particularly the fishes of it, which are innumerable; and so Aben Ezra and Jarchi interpret it; and which sense is mentioned by Kimchi and Ben Melech:

his name should not have been cut off nor destroyed from before me :
the name of Israel, as the Targum has it; the name of the people of the Jews is no more in the land where they dwelt; they are cut off as a nation; their city and temple are destroyed, where they appear no more before the Lord; which would not have been, had they hearkened to the Messiah, embraced his truths, and been obedient to his commands.

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FOOTNOTES:

• F17: (wytemk) "sicut viscera ejus", Montanus; "interiora maris"; Munster.