John Gill Commentary Isaiah 5:12

"And the harp and the lute, the tabret and the pipe, and wine, are [in] their feasts; but they regard not the work of Jehovah, neither have they considered the operation of his hands." — Isaiah 5:12 (ASV)

And the harp, and the viol, the tabret, and pipe Instruments of music; some struck with a bow or quill, or touched with the fingers; and others blown with the mouth: and wine are in their feasts; so that they lived jovially and merrily, like sons of Bacchus, more than like the people of God:

but they regard not the work of the Lord, neither consider the operation of his hands;

meaning not the law, as the Targum and Kimchi, which was the work of the Lord, and the writing of his hands; rather, as Aben Ezra, the punishment inflicted on the ten tribes being carried into captivity; or else the works of creation and providence, and the daily mercies of life; or, best of all, the great work of redemption by Christ, and the conversion of sinners, both among Jews and Gentiles, by the preaching of his Gospel; for this refers to the Jews in the times of Christ and his apostles, which immediately preceded their utter destruction; and those sins here mentioned were the cause of it. See (Psalms 28:5) .