John Gill Commentary Isaiah 5:6

"and I will lay it waste; it shall not be pruned nor hoed; but there shall come up briers and thorns: I will also command the clouds that they rain no rain upon it." — Isaiah 5:6 (ASV)

And I will lay it waste
Or "desolate", as it was by the Romans: the whole land of Judea, as well as the city and temple (Matthew 23:38).

it shall not be pruned nor digged ; as vineyards are, to make them more fruitful; but no care shall be taken of it, no means made use of to cultivate it, all being ineffectual:

but there shall come up briers and thorns ; sons of Belial, wicked and ungodly men; immoralities, errors, heresies, contentions, quarrels, &c. which abounded about the time of Jerusalem's destruction, and before:

I will also command the clouds that they rain no rain upon them ; by "the clouds" are meant the apostles of Christ, who were full of the doctrines of grace, from whom they dropped as rain upon the mown grass; these, when the Jews contradicted and blasphemed the Gospel, and judged themselves unworthy of it, were commanded by Christ to turn from them, and go to the Gentiles, (Acts 13:45–47) (Zechariah 14:17Zechariah 14:18) (Revelation 11:6) agreeably to this sense is the Targum,

``and I will command the prophets, that they do not prophesy upon them prophecy.''