John Gill Commentary Isaiah 51:21

"Therefore hear now this, thou afflicted, and drunken, but now with wine:" — Isaiah 51:21 (ASV)

Therefore hear now this, you afflicted
By Babylon, by antichrist and his followers; hear, for your comfort, the following prophecy: and drunken, but not with wine ;
not with wine in a literal sense; nor with the wine of the fornication of the whore of Rome; nor with idolatry, as the kings of the earth are said to be, (Revelation 17:2) (18:3) but, as the Targum expresses it, with tribulation; with afflictions at the hand of God, and persecutions from men.