John Gill Commentary Jeremiah 16:2

"Thou shalt not take thee a wife, neither shalt thou have sons or daughters, in this place." — Jeremiah 16:2 (ASV)

You shall not take yourself a wife Not because it was unlawful; for it was lawful for prophets to marry, and they did; but because it was not advisable, on account of the calamities and distresses which were coming upon the nation; which would be more bearable by him alone, than if he had a wife, which would increase his care, concern, and sorrow. Neither shall you have sons nor daughters in this place ; in Anathoth, says Kimchi; but it is most likely that Jerusalem in particular is meant, though the whole land of Judea in general may be designed; and though nothing is more desirable than to have children to build up the family, and bear and continue a man's name for futurity, yet in times of public calamity these do but add to the affliction.