John Gill Commentary Jeremiah 21:6

"And I will smite the inhabitants of this city, both man and beast: they shall die of a great pestilence." — Jeremiah 21:6 (ASV)

And I will smite the inhabitants of this city
With one or other of his arrows after mentioned: or, "them that abide in this city" {o}^F15; that do not go out of it, and surrender themselves to the king of Babylon; see (Jeremiah 21:9) ; both man and beast ;
the latter for the sin of the former; particularly such beasts as were fit for food are meant, whereby the famine would be increased, and so the greater destruction of men: they shall die of a great pestilence ;
both man and beast; a disease which comes immediately from the hand of God; hence Hippocrates used to call it (to yeion) , "the divine disease": here it denotes a very uncommon one, which should sweep away large numbers; called great, both for quality, or the nature of it, and for the quantity of persons that died of it.

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FOOTNOTES:

• F15: (ryeh ybvwy ta) "manentes in hac urbe", Gataker.