John Gill Commentary Jeremiah 22:21

"I spake unto thee in thy prosperity; but thou saidst, I will not hear. This hath been thy manner from thy youth, that thou obeyedst not my voice." — Jeremiah 22:21 (ASV)

I spoke to you in your prosperity
Or "prosperities", or "tranquillities" ^F25 ; when in their greatest affluence, in the height of it; this he did, when he sent to them his servants the prophets, as the Targum, and by them exhorted, reproved, and advised them: [but] you said, I will not hear ;
this was the language of their hearts and actions, though not of their mouths: this has been your manner from your youth ;
from the time they came out of Egypt, and first became a church and body politic; while they were in the wilderness; or when first settled in the land of Canaan: this was the infancy of their state; and from that time it was their manner and custom to reject the word of the Lord, and turn a deaf ear to it: that you do not obey my voice ;
in his law, and by his prophets.

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FOOTNOTES:

• F25: (Kytwlvb) "in tranquillitatibus fuis", Vatablus, Cocceius, Schmidt; "felicitatibus tuis", Pagninus; "securitatibus tuis", Montanus.