John Gill Commentary Jeremiah 49:17

"And Edom shall become an astonishment: every one that passeth by it shall be astonished, and shall hiss at all the plagues thereof." — Jeremiah 49:17 (ASV)

Also Edom shall be a desolation
Not only Bozrah, its principal city, before spoken of, but the whole country of Idumea should be laid waste; its fortified cities destroyed; its riches plundered; and its inhabitants slain with the sword; or carried captive.

everyone that goes by it shall be astonished ;
at the desolation made, so suddenly and so universally.

and shall hiss at all the plagues of it ;
rejoice at them; clap their hands, and shake their heads, as the Targum; and hiss with their tongues, insulting and deriding them.