John Gill Commentary Jeremiah 50:12

"your mother shall be utterly put to shame; she that bare you shall be confounded: behold, she shall be the hindermost of the nations, a wilderness, a dry land, and a desert." — Jeremiah 50:12 (ASV)

Your mother shall be sore confounded
The monarchy of the Chaldeans; so the Targum and jarchi, your congregation; or rather their metropolis, their mother city, the city of Babylon; which would be confounded when taken, none of her sons being able to defend her: the same will be true of mystical Babylon, the mother of harlots, (Revelation 17:5) ;

she that bare you shall be ashamed ;
which is the same as before, in different words: behold, the hindermost of the nations [shall be] a wilderness, a dry
land, and a desert ;
or, as the Vulgate Latin version, "she shall be the last among the nations"; she that was the head of them, signified by the head of gold in Nebuchadnezzar's image, shall now be the tail of them, and become like a dry land and desert, without inhabitants, having neither men nor cattle in it; see (Jeremiah 50:3) ;

or, as Jarchi and Kimchi, their end, "the latter end" ^F13 of the kingdom of Babylon; or what should befall that people in their last days would be, that their land should become a wilderness, the habitants being slain, and none to till it; or Babylon is called the last of the nations, because her punishment, in order of time, was last, as Gussetius ^F14 thinks; (Jeremiah 25:26) .

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FOOTNOTES:

• F13: (Mywg tyrxa) "finis seu extremitas gentium", Vatablus, Montanus, Schmidt.
• F14: Comment. Ebr. p. 30.