John Gill Commentary Jeremiah 50:39

"Therefore the wild beasts of the desert with the wolves shall dwell there, and the ostriches shall dwell therein: and it shall be no more inhabited for ever; neither shall it be dwelt in from generation to generation." — Jeremiah 50:39 (ASV)

Therefore the wild beasts of the desert with the wild beasts
of the islands shall dwell [there]
Of these creatures (See Gill on Isaiah 13:21); and (See Gill on Isaiah 13:22);

and the owls shall dwell therein ;
so mystical Babylon when fallen shall become the habitation of devils, the hold of every foul spirit, and a cage of every unclean and hateful bird, (Revelation 18:2) ;

and it shall be no more inhabited for ever; neither shall it be dwelt
in from generation to generation ;
interpreters observe that this was gradually accomplished: it was taken by Cyrus, and made tributary to the Persians; the seat of the empire was removed from it; its walls were demolished by Darius; it was drained both of its inhabitants and its riches through Seleucus Nicator building the city Seleucia ^F18 near it. In Adrian's time there was nothing but an old wall left; and in Jerom's time it was a park for the king of Persia to hunt in; (See Gill on Jeremiah 50:13); and (See Gill on Isaiah 13:20);

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FOOTNOTES:

• F18: Plin. Nat. Hist. l. 6. c. 26.