John Gill Commentary Lamentations 3:66

"Thou wilt pursue them in anger, and destroy them from under the heavens of Jehovah." — Lamentations 3:66 (ASV)

Persecute and destroy them in anger As they have persecuted the people of God, do you persecute them; and never leave pursuing them until you have made a full end of them, as the effect of vindictive wrath and vengeance:

from under the heavens of the Lord which are made by him, and in which he dwells; let them not have the benefit of them, nor so much as the sight of them; but let them perish from under them, (Jeremiah 10:11) .