John Gill Commentary Proverbs 21:10

"The soul of the wicked desireth evil: His neighbor findeth no favor in his eyes." — Proverbs 21:10 (ASV)

The soul of the wicked desires evil
The evil of sin, it being natural to him; he chooses it, delights in it, craves after it, under a notion of pleasure or profit: or the evil of mischief; it is a sport and pastime to him to do injury to others; see (Proverbs 10:23) ; he desires both the one and the other with all his soul; his heart is in it, he is set upon it, which shows him to be a wicked man;

his neighbour finds no favour in his eyes ;
not only he delights to do mischief to an enemy or a stranger, but even to a neighbour and friend; he will do him no kindness, though he asks it of him; he will show him no mercy, though an object of it; he will spare him not, but do him an injury, if he attempts to hinder or dissuade him from doing mischief, or reproves him for it.