John Gill Commentary Psalms 102:17

"He hath regarded the prayer of the destitute, And hath not despised their prayer." — Psalms 102:17 (ASV)

He will regard the prayer of the destitute
Of the destitute of human help and support, protection and defence; as the church in the wilderness; of the "poor", as the Syriac and Arabic versions, both in spirit and in purse; of the "humble", as the Septuagint and Vulgate Latin: the word ^F3 signifies a low shrub or plant; it is rendered, the heath in the wilderness, (Jeremiah 17:6) and designs the saints in their low and afflicted state, during the reign of antichrist, and while the witnesses prophesy in sackcloth;

these are the elect that pray day and night, and give the Lord no rest till he establish and make Jerusalem a praise in the earth; and the prayers of these are regarded and looked to by the Lord; his eyes are upon and his ears are open to these praying ones; and all the glorious things which shall be done for the church of God will be in consequence of their prayers:

and not despise their prayer ;
not reject it with contempt and abhorrence; more is intended than is expressed: the meaning is, that he will receive it with pleasure, and return an answer to it; the prayer of these poor destitute ones is delightful to him, (Proverbs 15:8) .

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FOOTNOTES:

• F3: (rereh) "eorum, qui sunt veluti myricae", Pagninus, Vatablus, Cocceius.