John Gill Commentary Psalms 21:10

"Their fruit wilt thou destroy from the earth, And their seed from among the children of men." — Psalms 21:10 (ASV)

Their fruit shall you destroy from the earth

Meaning the offspring of wicked men; the fruit of the womb, (Psalms 127:3) ; the same with their seed in the next clause:

and their seed from among the children of men

see (Psalms 37:28) ; which must be understood of such of their seed, and offspring as are as they were when born; are never renewed and sanctified, but are like their parents; as the Jews were, their parents were vipers, and they were serpents, the generation of them; and were the children of the devil, and did his works:

now these passages had their accomplishment in the Jews, when the day of God's wrath burnt them up, and left them neither root nor branch, (Malachi 4:1) ; and in the Pagan empire, when every mountain and island were moved out of their places, and the Heathen perished out of the land, (Revelation 6:14) (Psalms 10:16) ; and will be further accomplished when the Lord shall punish the wicked woman Jezebel, the antichristian harlot, and kill her children with death, (Revelation 2:23) ; see (Psalms 104:35) .