Matthew Henry Commentary Genesis 22:15-19

"And the angel of Jehovah called unto Abraham a second time out of heaven, and said, By myself have I sworn, saith Jehovah, because thou hast done this thing, and hast not withheld thy son, thine only son, that in blessing I will bless thee, and in multiplying I will multiply thy seed as the stars of the heavens, and as the sand which is upon the seashore. And thy seed shall possess the gate of his enemies. And in thy seed shall all the nations of the earth be blessed. Because thou hast obeyed my voice. So Abraham returned unto his young men, and they rose up and went together to Beer-sheba. And Abraham dwelt at Beer-sheba." — Genesis 22:15-19 (ASV)

There are high declarations of God's favor to Abraham in this confirmation of the covenant with him, exceeding any he had been blessed with before. Those who are willing to part with anything for God will have it made up to them with unspeakable advantage. The promise (Genesis 22:18) doubtless points to the Messiah and the grace of the gospel.

By this we know the loving-kindness of God our Savior towards sinful man, in that he has not withheld his Son, his only Son, from us. By this we perceive the love of Christ, in that he gave himself a sacrifice for our sins. Yet he lives, and calls to sinners to come to him, and partake of his blood-bought salvation. He calls to his redeemed people to rejoice in him, and to glorify him.

What then shall we render for all his benefits? Let his love constrain us to live not to ourselves, but to Him who died for us, and rose again. Admiring and adoring His grace, let us devote our all to his service, who laid down his life for our salvation. Whatever is dearest to us on earth is our Isaac.

And the only way for us to find comfort in an earthly thing is to give it by faith into the hands of God. Yet remember that Abraham was not justified by his readiness to obey, but by the infinitely more noble obedience of Jesus Christ; his faith, receiving this, relying on this, and rejoicing in this, inclined him to and made him capable of such wonderful self-denial and duty. (Genesis 22:20–24)