Matthew Henry Commentary Genesis 4:25-26

"And Adam knew his wife again; and she bare a son, and called his name Seth. For, [said she], God hath appointed me another seed instead of Abel; for Cain slew him. And to Seth, to him also there was born a son; and he called his name Enosh. Then began men to call upon the name of Jehovah." — Genesis 4:25-26 (ASV)

Our first parents were comforted in their affliction by the birth of a son, whom they called Seth, that is, “set,” “settled,” or “placed”; in his seed mankind should continue to the end of time, and from him the Messiah should descend. While Cain, the head of the apostasy, is made a wanderer, Seth, from whom the true church was to come, is fixed.

In Christ and his church is the only true settlement. Seth walked in the steps of his martyred brother Abel; he was a partaker of like precious faith in the righteousness of our God and Saviour Jesus Christ, and so became a fresh witness of the grace and influence of God the Holy Spirit. God enabled Adam and Eve to see the revival of religion in their family.

The worshippers of God began to do more in religion; some, by an open profession of true religion, protested against the wickedness of the world around. The worse others are, the better we should be, and the more zealous. Then began the distinction between professors and the profane, which has been kept up ever since, and will be, while the world stands.