Matthew Henry Commentary Jeremiah 2:20-28

"For of old time I have broken thy yoke, and burst thy bonds; and thou saidst, I will not serve; for upon every high hill and under every green tree thou didst bow thyself, playing the harlot. Yet I had planted thee a noble vine, wholly a right seed: how then art thou turned into the degenerate branches of a foreign vine unto me? For though thou wash thee with lye, and take thee much soap, yet thine iniquity is marked before me, saith the Lord Jehovah. How canst thou say, I am not defiled, I have not gone after the Baalim? see thy way in the valley, know what thou hast done: [thou art] a swift dromedary traversing her ways; a wild ass used to the wilderness, that snuffeth up the wind in her desire; in her occasion who can turn her away? all they that seek her will not weary themselves; in her month they shall find her. Withhold thy foot from being unshod, and thy throat from thirst: but thou saidst, It is in vain; no, for I have loved strangers, and after them will I go. As the thief is ashamed when he is found, so is the house of Israel ashamed; they, their kings, their princes, and their priests, and their prophets; who say to a stock, Thou art my father; and to a stone, Thou hast brought me forth: for they have turned their back unto me, and not their face; but in the time of their trouble they will say, Arise, and save us. But where are thy gods that thou hast made thee? let them arise, if they can save thee in the time of thy trouble: for according to the number of thy cities are thy gods, O Judah." — Jeremiah 2:20-28 (ASV)

Despite all their advantages, Israel had become like the wild vine that bears poisonous fruit. People are often as much under the power of their unbridled desires and their sinful lusts as brute animals.

But the Lord here warns them not to weary themselves in pursuits that could only bring distress and misery. Just as we must not despair of God's mercy, but believe it is sufficient for the pardon of our sins, so also we must not despair of God's grace, but believe it is able to subdue our corruptions, no matter how strong.