Matthew Henry Commentary Jeremiah 46:1-12

"The word of Jehovah which came to Jeremiah the prophet concerning the nations. Of Egypt: concerning the army of Pharaoh-neco king of Egypt, which was by the river Euphrates in Carchemish, which Nebuchadrezzar king of Babylon smote in the fourth year of Jehoiakim the son of Josiah, king of Judah. Prepare ye the buckler and shield, and draw near to battle. Harness the horses, and get up, ye horsemen, and stand forth with your helmets; furbish the spears, put on the coats of mail. Wherefore have I seen it? they are dismayed and are turned backward; and their mighty ones are beaten down, and are fled apace, and look not back: terror is on every side, saith Jehovah. Let not the swift flee away, nor the mighty man escape; in the north by the river Euphrates have they stumbled and fallen. Who is this that riseth up like the Nile, whose waters toss themselves like the rivers? Egypt riseth up like the Nile, and his waters toss themselves like the rivers: and he saith, I will rise up, I will cover the earth; I will destroy cities and the inhabitants thereof. Go up, ye horses; and rage, ye chariots; and let the mighty men go forth: Cush and Put, that handle the shield; and the Ludim, that handle and bend the bow. For that day is [a day] of the Lord, Jehovah of hosts, a day of vengeance, that he may avenge him of his adversaries: and the sword shall devour and be satiate, and shall drink its fill of their blood; for the Lord, Jehovah of hosts, hath a sacrifice in the north country by the river Euphrates. Go up into Gilead, and take balm, O virgin daughter of Egypt: in vain dost thou use many medicines; there is no healing for thee. The nations have heard of thy shame, and the earth is full of thy cry; for the mighty man hath stumbled against the mighty, they are fallen both of them together." — Jeremiah 46:1-12 (ASV)

The whole word of God is against those who do not obey the gospel of Christ; but it is for those, even Gentiles, who turn to Him. The prophecy begins with Egypt. Let them strengthen themselves with all the skill and influence they command, yet it will all be in vain. The wounds God inflicts on His enemies cannot be healed by medicines. Power and prosperity soon pass from one to another in this changing world.