Commentators explain this verse as a profound statement on God's sovereignty. While the brothers' intentions were purely evil, God was actively working His own good plan. Scholars like Calvin and Gill note that God sovereignly ordained the outcome for good (saving many lives) without being the author of the brothers' sin. This provides great comfort, showing that God can turn even malicious human actions to serve His ultimate, redemptive purpose, much like He did with the cross of Christ.