Commentators explain that this verse isn't about God ignoring any person in trouble. Instead, it highlights that God does not respond to the cry of a hypocrite who calls out only for selfish relief, with no genuine remorse or intention to change. As Albert Barnes clarifies, if a person comes with a truly penitent heart, God will hear them. The issue is the insincere, "double-tongued" prayer of someone who plans to return to sin once the trouble passes.