The people of Nazareth knew Jesus' family intimately, including his sisters who lived among them. Commentators like Spurgeon and Henry point out the tragic irony: this closeness, which should have fostered pride, instead led to disbelief. They couldn't reconcile the man they knew from a humble background with his extraordinary wisdom and power. This serves as a warning that familiarity with Jesus can become an obstacle to true faith if we fail to see the divine beyond the human.