Commentators emphasize that Paul's first response isn't a detailed explanation but a powerful rebuke: "O man, who are you...?" This question is designed to humble the reader, reminding us of our status as finite, created beings before an infinite Creator. Scholars like Albert Barnes and John Gill note that it's inappropriate and arrogant for us, with our limited understanding, to sit in judgment of God's sovereign plans. The proper response is reverence, not argument.