A.T. Robertson Commentary Acts 28:22

"But we desire to hear of thee what thou thinkest: for as concerning this sect, it is known to us that everywhere it is spoken against." — Acts 28:22 (ASV)

But we desire (αξιουμεν δε). Old verb αξιοω, to deem worthy, to think right or proper as in 15:38 which see. They think it only fair to hear Paul's side of his case.

Concerning this sect (περ της αιρεσεως ταυτης). Paul had identified Christianity with Judaism (verse 20) in its Messianic hope. The language seems to imply that the number of Christians in Rome was comparatively small and mainly Gentile. If the edict of Claudius for the expulsion of the Jews from Rome (Acts 18:2) was due to disturbance over Christ (Χρηστυς), then even in Rome the Jews had special reason for hostility towards Christians.

Everywhere spoken against (πανταχου αντιλεγετα). Cf. verse 19. The line of cleavage between Jew and Christian was now sharply drawn everywhere.